童德文
一、简介
童德文，男，汉族，博士，三级教授，博士生导师，教育部高等学校动物医学类教学指导委员会委员，中国兽医协会教育工作委员会委员，国家林业和草原局教材建设专家委员会委员，教育部新世纪优秀人才。陕西省高等学校教学指导委员会委员，陕西省重点科技创新团队“动物重大疫病新型疫苗研发创新团队”带头人，陕西省教学团队“基础兽医学教学团队”带头人，陕西省精品资源共享课程“动物病理解剖学”负责人。5848vip威尼斯电子游戏教学指导委员会委员，5848vip威尼斯电子游戏基础兽医学科带头人。兼任中国畜牧兽医学会动物病理学分会常务理事，中国畜牧兽医学会动物毒物学分会常务理事，陕西省畜牧兽医学会副理事长，《动物医学进展》副主编，国家科技奖评审专家和国家自然科学基金评审专家等。
1994年7月研究生毕业获硕士学位并留校从事动物病理学教研工作。2001年1月获博士学位，同年12月晋升副教授，2002年遴选为硕士生导师。2005年被评为5848vip威尼斯电子游戏首批青年学术骨干，同年在新西兰Lincoln University研修。2007年遴选为博士生导师。近年来，主持国家自然科学基金、国际科学基金和陕西省特色产业链等项目30余项，相关研究成果发表于PLoS Pathogens, Journal of Virology, Journal of Immunology, Journal of Biological Chemistry等期刊，获批国家发明专利10余项，制定了多项猪病防控企业标准，获得陕西省教学成果特等奖、二等奖各1项。荣获唐立新教学名师、研究生教育优秀导师等称号。
二、研究方向
动物病理、细胞生理及病理。
主要研究领域：
1.动物疫病病原与宿主细胞互作机制研究；
2.动物疫病新型疫苗研发。
三、代表性论文
1. Xiujuan Zhang#, Peipei Ma#, Ting Shao, Yingli Xiong, Qian Du, Songbiao Chen, Bichen Miao, Xuezhi Zhang, Xiaoya Wang, Yong Huang*, Dewen Tong*. Porcine parvovirus triggers autophagy through the AMPK/Raptor/mTOR pathway to promote viral replication in porcine placental trophoblasts. Veterinary Research . 2022. 53(1): 33.
2. Zhenyu Wang#, Jing Chen#, Qiong-Ge Zhang, Kai Huang, Dan Ma, Qian Du, Dewen Tong*, Yong Huang*. Porcine circovirus type 2 infection inhibits the activation of type I interferon signaling via capsid protein and host gC1qR. Veterinary Microbiology . 2022. 266: 109354.
3. Bichen Miao#, Songbiao Chen#, Xuezhi Zhang, Peipei Ma, Mengyu Ma, Caiyi Chen, Xiujuan Zhang, Lingling Chang, Qian Du, Yong Huang*, Dewen Tong*. T598 and T601 phosphorylation sites of canine parvovirus NS1 are crucial for viral replication and pathogenicity. Veterinary Microbiology . 2022. 264: 109301.
4. Wenlong Zhang, Zelin Zhang, Jiang Peng, Sitian Yang, Dewen Tong*. Effects of melatonin on the production of GnRH and LH in luteal cells of pregnant sows. Journal of Molecular Endocrinology . 2022. 68(2): 111-123.
5. Lin Liang, Donghui Liu, Zhaocai Li, Jizhang Zhou*, Dewen Tong*. Chlamydia abortus OmcB protein is essential for adhesion to host cells. Journal of Basic Microbiology . 2021. 61(12): 1145-1152.
6. Liyan Cao, Fang Fu, Jianfei Chen, Hongyan Shi, Xin Zhang, Jianbo Liu, Da Shi, Yong Huang, Dewen Tong*, Li Feng*. Nucleocytoplasmic Shuttling of Porcine Parvovirus NS1 Protein Mediated by the CRM1 Nuclear Export Pathway and the Importin α/β Nuclear Import Pathway. Journal of Virology . 2022. 96(1): e0148121.
7. Lingling Chang, Yanping Qi, Yamian Wang, Chen-Hsuan Liu, Songbiao Chen, Bichen Miao, Dewen Tong*. Systemic mucormycosis caused by Rhizopus microsporus in a captive bottlenose dolphin. Veterinary Medicine and Science . 2021. 7(6): 2404-2409.
8. Zhenyu Wang#, Jing Chen#, Xingchen Wu, Dan Ma, Xiaohua Zhang, Ruizhen Li, Cong Han, Haixin Liu, Xiangrui Yin, Qian Du, Dewen Tong*, Yong Huang*. PCV2 targets cGAS to inhibit type I interferon induction to promote other DNA virus infection. PLoS Pathogens . 2021. 17(9): e1009940.
9. Ruizhen Li#, Wenli Liu#, Xiangrui Yin, Fangfang Zheng, Zhenyu Wang, Xingchen Wu, Xiaohua Zhang, Qian Du, Yong Huang*, Dewen Tong*. Brucella spOmp25 Promotes Proteasome-Mediated cGAS Degradation to Attenuate IFN-β Production. Frontiers in Microbiology . 2021. 12: 702881.
10. Jianxiong Guo#, Xiaomin Zhao#, Zhihao Liu, Dan Liu, Xiaoyi Tang, Kaili Wang, Mengli Wang, Yong Huang*, Dewen Tong*. Transmissible gastroenteritis virus ORF3b up-regulates miR-885-3p to counteract TNF-α production via inhibiting NF-κB pathway. Veterinary Microbiology . 2021. 261: 109189.
11. Songbiao Chen#, Nannan Chen#, Bichen Miao, Jiang Peng, Xuezhi Zhang, Caiyi Chen, Xiujuan Zhang, Lingling Chang, Qian Du, Yong Huang*, Dewen Tong*. Coatomer protein COPƐ, a novel NS1-interacting protein, promotes the replication of Porcine Parvovirus via attenuation of the production of type I interferon. Veterinary Microbiology . 2021. 261: 109188.
12. Lin Liang, Yuan Wen, Zhaocai Li, Ping Liu, Xing Liu, Shuming Tan, Donghui Liu, Jizhang Zhou*, Dewen Tong*. Seroprevalence of Chlamydia abortus infection in yak (Bos grunniens) in Tibet, China. Irian Veterinary Journal . 2021. 74(1): 19.
13. Xiaoya Wang#, Hai Zhang#, Rui Guo, Xiaomin Li, Haixin Liu, Zhenyu Wang, Qian Du, Dewen Tong*, Yong Huang*. MicroRNA-223 modulates the IL-4-medicated macrophage M2-type polarization to control the progress of sepsis. International Immunopharmacology. 2021. 96: 107783.
14. Songbiao Chen#, Bichen Miao#, Nannan Chen, Caiyi Chen, Ting Shao, Xuezhi Zhang, Lingling Chang, Xiujuan Zhang, Qian Du, Yong Huang*, Dewen Tong*. SYNCRIP facilitates porcine parvovirus viral DNA replication through the alternative splicing of NS1 mRNA to promote NS2 mRNA formation. Veterinary Research. 2021. 52(1): 73.
15. Xingchen Wu#, Zhenyu Wang#, Dan Qiao, Yu Yuan, Cong Han, Nan Yang, Ruizhen Li, Qian Du, Dewen Tong*, Yong Huang*. Porcine circovirus type 2 infection attenuates the K63-linked ubiquitination of STING to inhibit IFN-β induction via p38-MAPK pathway. Veterinary Microbiology. 2021. 258: 109098.
16. Lingling Chang, Qiaoxing Wu, Ruiping She, Dewen Tong*. The pathologic lesions of liver caused by melamine alone or in combination with cyanuric acid in mice. Research in Veterinary Science. 2021. 136: 230-238.
17. Lingling Chang#, Yanping Qi#, Dan Liu, Qian Du, Xiaomin Zhao, Dewen Tong*. Molecular detection and genotyping of bovine viral diarrhea virus in Western China. BMC Veterinary Research . 2021. 17(1): 66.
18. Cong Han#, Qian Du#, Lei Zhu, Nannan Chen, Le Luo, Qiao Chen, Jiatong Yin, Xingchen Wu, Dewen Tong*, Yong Huang*. Porcine DNAJB6 promotes PCV2 replication via enhancing the formation of autophagy in host cells. Veterinary Research. 2020. 51(1): 61.
19. Le Luo, Jing Chen, Xiaomin Li, Dan Qiao, Zhenyu Wang, Xingchen Wu, Qian Du, Dewen Tong*, Yong Huang*. Establishment of method for dual simultaneous detection of PEDV and TGEV by combination of magnetic micro-particles and nanoparticles. Journal of Infection and Chemotherapy. 2020. 26(5): 523-526.
20. Songbiao Chen#, Bichen Miao#, Nannan Chen, Xuezhi Zhang, Xiujuan Zhang, Qian Du, Yong Huang*, Dewen Tong*. A novel porcine parvovirus DNA-launched infectious clone carrying stable double labels as an effective genetic platform. Veterinary Microbiology. 2020. 240:108502.
21. Xiujuan Zhang#, Yingli Xiong#, Jie Zhang, Ting Shao, Songbiao Chen, Bichen Miao, Zhenyu Wang, Qian Du, Yong Huang*, Dewen Tong*. Autophagy Promotes Porcine Parvovirus Replication and Induces Non-Apoptotic Cell Death in Porcine Placental Trophoblasts. Viruses. 2019. 12(1): 15.
22. Xingchen Wu#, Xiaoya Wang#, Tengfei Shi, Le Luo, Dan Qiao, Zhenyu Wang, Cong Han, Qian Du, Dewen Tong*, Yong Huang*. Porcine Circovirus Type 2 Rep Enhances IL-10 Production in Macrophages via Activation of p38-MAPK Pathway. Viruses. 2019. 11(12): 1141.
23. Xuelian Ma#, Xiaomin Zhao#, Kaili Wang, Xiaoyi Tang, Jianxiong Guo, Mi Mi, Yanping Qi, Lingling Chang, Yong Huang, Dewen Tong*. Identification and analysis of long non-coding RNAs that are involved in inflammatory process in response to transmissible gastroenteritis virus infection. BMC Genomics. 2019. 20(1): 806.
24. Xiaomin Zhao#, Xuelian Ma#, Jianxiong Guo, Mi Mi, Kaili Wang, Chuyi Zhang, Xiaoyi Tang, Lingling Chang, Yong Huang, Dewen Tong*. Circular RNA CircEZH2 Suppresses Transmissible Gastroenteritis Coronavirus-induced Opening of Mitochondrial Permeability Transition Pore via Targeting MiR-22 in IPEC-J2. International Journal of Biology Science. 2019. 15(10): 2051-2064.
25. Zheng Lu#, Lingling Chang#, Hongbo Zhou, Xiaoqiang Liu, Yinqian Li, Tiejun Mi, Dewen Tong*. Arctigenin Attenuates Tumor Metastasis Through Inhibiting Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma via Suppressing GSK3β-Dependent Wnt/β-Catenin Signaling Pathway In Vivo and In Vitro. Frontiers in Pharmacology. 2019. 10: 937.
26. Qian Du#, Huan Zhang#, Mingrui He, Xuan Zhao, Jia He, Beibei Cui, Xuefeng Yang, Dewen Tong*, Yong Huang*. Interleukin-10 Promotes Porcine Circovirus Type 2 Persistent Infection in Mice and Aggravates the Tissue Lesions by Suppression of T Cell Infiltration. Frontiers in Microbiology. 2019. 10: 2050.
27. Tongtong Wang#, Qian Du#, Yingying Niu, Xiaohua Zhang, Zhenyu Wang, Xingchen Wu, XueFeng Yang, Xiaomin Zhao, Shan-Lu Liu, Dewen Tong*, Yong Huang*. Cellular p32 Is a Critical Regulator of Porcine Circovirus Type 2 Nuclear Egress. Journal of Virology. 2019. 93(23): e00979-19.
28. Songbiao Chen#, Bichen Miao#, Huan Zhang, Yingli Xiong, Xiujuan Zhang, Ting Shao, Jia He, Qian Du, Yong Huang*, Dewen Tong*. Construction and characterization of the infectious clone of porcine parvovirus carrying genetic marker. Veterinary Microbiology. 2019. 235: 143-150.
29. Wenlong Zhang, Jinxuan Chen, Yongxin Zhao, Zhi Zheng, Yanliang Song, Hao Wang*, Dewen Tong*. The inhibitory effect of melatonin on mammary function of lactating dairy goats. Biology of Reproduction. 2019. 100(2): 455-467.
30. Xuelian Ma#, Xiaomin Zhao#, Zhichao Zhang, Jianxiong Guo, Lijuan Guan, Juejun Li, Mi Mi, Yong Huang, Dewen Tong*. Differentially expressed non-coding RNAs induced by transmissible gastroenteritis virus potentially regulate inflammation and NF-κB pathway in porcine intestinal epithelial cell line. BMC Genomics. 2018. 19(1): 747.
31. Xiaomin Zhao#, Xiangjun Song#, Xiaoyuan Bai, Zhanhang Tan, Xuelian Ma, Jianxiong Guo, Zhichao Zhang, Qian Du, Yong Huang, Dewen Tong*. microRNA-222 Attenuates Mitochondrial Dysfunction During Transmissible Gastroenteritis Virus Infection. Molecular & Cellular Proteomics . 2019. 18(1): 51-64.
32. Lingling Chang#, Zheng Lu#, Delong Li, Liang Zhang, Zhenyu Wang, Qian Du, Yong Huang, Xiaomin Zhao, Dewen Tong*. Melamine causes testicular toxicity by destroying blood-testis barrier in piglets. Toxicology Letters. 2018. 296: 114-124.
33. Qi Zhang, Ying Xu, Rong Chang, Dewen Tong*, Xingang Xu*. Transmissible gastroenteritis virus N protein causes endoplasmic reticulum stress, up-regulates interleukin-8 expression and its subcellular localization in the porcine intestinal epithelial cell. Research in Veterinary Science. 2018. 119: 109-115.
34. Zheng Lu, Lingling Chang, Qian Du, Yong Huang, Xiujuan Zhang, Xingchen Wu, Jie Zhang, Ruizhen Li, Zelin Zhang, Wenlong Zhang, Xiaomin Zhao, Dewen Tong*. Arctigenin Induces an Activation Response in Porcine Alveolar Macrophage Through TLR6-NOX2-MAPKs Signaling Pathway. Frontiers in Pharmacology . 2018. 9: 475.
35. Qian Du#, Xingchen Wu#, Tongtong Wang#, Xuefeng Yang, Zhenyu Wang, Yingying Niu, Xiaomin Zhao, Shan-Lu Liu, Dewen Tong*, Yong Huang*. Porcine Circovirus Type 2 Suppresses IL-12p40 Induction via Capsid/gC1qR-Mediated MicroRNAs and Signalings. Journal of Immunology . 2018. 201(2): 533-547.
36. Tongtong Wang#, Qian Du#, Xingchen Wu, Yingying Niu, Lijuan Guan, Zhenyu Wang, Xiaomin Zhao, Shan-Lu Liu, Dewen Tong*, Yong Huang*. Porcine MKRN1 modulates the replication and pathogenesis of PCV2 by inducing capsid protein ubiquitination and degradation. Journal of Virology .2018. 92(11): e00100-18.
37. Liang Zhang, Zhenyu Wang, Jie Zhang, Xiaomao Luo, Qian Du, Lingling Chang, Xiaomin Zhao, Yong Huang*, Dewen Tong*. Porcine parvovirus infection impairs progesterone production in luteal cells through MAPKs, p53 and mitochondria-mediated apoptosis. Biology of Reproduction. 2018. 98(4): 558-569.
38. Xiaomin Zhao#, Xiaoyuan Bai#, Lijuan Guan, Juejun Li, Xiangjun Song, Xuelian Ma, Jianxiong Guo, Zhichao Zhang, Qian Du, Yong Huang, Dewen Tong*. MicroRNA-4331 promotes transmissible gastroenteritis virus (TGEV)-induced mitochondrial damage via targeting RB1, upregulating interleukin-1 receptor accessory protein (IL1RAP), and activating p38 MAPK pathway in vitro. Molecular & Cellular Proteomics. 2018. 17(2): 190-204.
39. Beibei Cui#, Wenli Liu#, Xiaoya Wang#, Yu Chen, Qian Du, Xiaomin Zhao, Hai Zhang, Shan-Lu Liu, Dewen Tong*, Yong Huang*. Brucella Omp25 upregulates miR-155, miR-21-5p, and miR-23b to inhibit interleukin-12 production via modulation of programmed death-1 signaling in human monocyte/macrophages. Frontiers in Immunology. 2017. 8(6): 1-15.
40. Xiaomao Luo#, Xiujuan Zhang#, Xingchen Wu, Xuefeng Yang, Cong Han, Zhenyu Wang, Xiaomin Zhao, Shan-Lu Liu, Dewen Tong*, Yong Huang*. Brucella down-regulates TNF-α to promote intracellular survival via Omp25 regulation of different microRNAs in porcine and murine macrophages. Frontiers in Immunology. 2018. 8(1): 1-17.
41. Wenlong Zhang, Zelin Zhang, Jinxuan Chen, Dewen Tong*. Ghrelin is expressed in the pregnant mammary glands of dairy goats and promotes the cell proliferation of mammary epithelial cells. General and Comparative Endocrinology. 2018. 260(12): 115-124.
42. Wenlong Zhang#, Zhenyu Wang#, Liang Zhang, Zelin Zhang, Jinxuan Chen, Weicong Chen, Dewen Tong*. Melatonin stimulates the secretion of progesterone along with the expression of cholesterol side-chain cleavage enzyme (P450scc) and steroidogenic acute regulatory protein (StAR) in corpus luteum of pregnant sows. Theriogenology. 2018. 108(2): 297-305.
43. Liang Zhang#, Yong Huang#, Zhenyu Wang, Xiaomao Luo, Hongling Zhang, Qian Du, Lingling Chang, Xiaomin Zhao, Dewen Tong*. Establishment and characterization of a telomerase immortalized porcine luteal cells. Theriogenology. 2017. 94(11): 105-113.
44. Delong Li#, Qian Du#, Bin Wu, Juejun Li, Lingling Chang, Xiaomin Zhao, Yong Huang*, Dewen Tong*. Immunogenicity of adenovirus vaccines expressing the PCV2 capsid protein in pigs. Vaccine. 2017. 35(36): 4722-4729.
45. Delong Li#, Dan Xu#, Zengguo Wang, Qian Du, Lingling Chang, Xiaomin Zhao, Yong Huang*, Dewen Tong*. Immunogenicity evaluation of modified adenovirus vaccines expressing porcine circovirus type 2 capsid protein in pigs. Viral Immunology. 2017. 30(2): 111-119.
46. Dan Xu#, Qian Du#, Cong Han, Zengguo Wang, Xiujuan Zhang, Tongtong Wang, Xiaomin Zhao, Yong Huang*, Dewen Tong*. p53 signaling modulation of cell cycle arrest and viral replication in porcine circovirus type 2 infection cells. Veterinary Research . 2016. 47(1): 120-131.
47. Hongling Zhang#, Yong Huang#, Lili Wang, Tingting Yu, Zengguo Wang, Lingling Chang, Xiaomin Zhao, Xiaomao Luo, Liang Zhang, Dewen Tong*. Immortalization of porcine placental trophoblast cells through reconstitution of telomerase activity. Theriogenology. 2016. 85(8): 1446-1456.
48. Delong Li#, Yong Huang#, Qian Du, Zhenyu Wang, Lingling Chang, Xiaomin Zhao, Dewen Tong*, CD40 Ligand and GMCSF coexpression enhance the immune responses and protective efficacy of PCV2 adenovirus vaccine. Viral Immunology. 2016. 29(3): 148-158.
49. Xiaomin Zhao#, Hailing Xiang#, Xiaoyuan Bai, Naijiao Fei, Yong Huang, Xiangjun Song, Hongling Zhang, Liang Zhang, Dewen Tong*. Porcine parvovirus infection activates mitochondria-mediated apoptotic signaling pathway by inducing ROS accumulation. Virology Journal. 2016. 13(1): 26-35.
50. Xiaomin Zhao#, Xiangjun Song#, Xiaoyuan Bai, Naijiao Fei, Yong Huang, Zhimin Zhao, Qian Du, Hongling Zhang, Liang Zhang, Dewen Tong*. miR-27b attenuates apoptosis induced by transmissible gastroenteritis virus (TGEV) infection via targeting runt-related transcription factor 1 (RUNX1). PeerJ. 2016. 4: 1635-1652.
51. Yunpeng Fan#, Xia Ma#, Jing Zhang, Lin Ma, Yuanyuan Gao, Weimin Zhang, Xiaoping Song*, Weifeng Hou, Chao Guo, Dewen Tong*. Ophiopogon polysaccharide liposome can enhance the non-specific and specific immune response in chickens. Carbohydrate Polymers. 2015. 119: 219-227.
52. Yunpeng Fan#, Meimei Ren#, Weifeng Hou, Chao Guo, Dewen Tong*, Lin Ma, Weimin Zhang, Mengmeng He, Xiaoping Song*. The activation of epimedium polysaccharide-propolis flavone liposome on Kupffer cells. Carbohydrate Polymers. 2015. 133: 613-623.
53. Xiangjun Song#, Xiaomin Zhao#, Yong Huang, Hailing Xiang, Wenlong Zhang, Dewen Tong*. Transmissible gastroenteritis virus (TGEV) infection alters the expression of cellular microRNA species that affect transcription of TGEV Gene 7. International Journal of Biological Sciences. 2015. 11(8): 913-922.
54. Xingang Xu#, Honglei Zhang#, Qi Zhang, Jie Dong, Yong Huang, Dewen Tong*. Porcine epidemic diarrhea virus M protein blocks cell cycle progression at S-phase and its subcellular localization in the porcine intestinal epithelial cells. Acta Virologica. 2015. 59(3): 265-275.
55. Hongling Zhang#, Yong Huang#, Qian Du, Xiaomao Luo, Liang Zhang, Xiaomin Zhao, Dewen Tong*. Porcine parvovirus infection induces apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated pathway. Biochemical and Biophysical Research Communications. 2015. 456(2): 649-655.
56. Li Ding#, Yong Huang#, Qian Du, Feng Dong, Xiaomin Zhao, Wenlong Zhang, Xingang Xu, Dewen Tong*. TGEV nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling. Biochemical and Biophysical Research Communications. 2014. 445(2): 497-503.
57. Yunpeng Fan, Xiaoping Song, Yuanyuan Gao, Ying Chen, Lin Ma, Weimin Zhang, Weifeng Hou, Chao Guo, Dewen Tong*. Preparation and optimization of ophiopogon polysaccharide liposome and its activity on Kupffer cells. International Journal of Pharmaceutics. 2014. 477(1-2): 421-430.
58. Yong Huang#, Feng Dong#, Qian Du, Hongling Zhang, Xiaomao Luo, Xiangjun Song, Xiaomin Zhao, Wenlong Zhang, Dewen Tong*. Swainsonine induces apoptosis through mitochondrial pathway and caspase activation in goat trophoblasts. International Journal of Biological Sciences. 2014. 10(7): 789-797.
59. Wei Li#, Yong Huang#, Xiaomin Zhao, Wenlong Zhang, Feng Dong, Qian Du, Dewen Tong*. Swainsonine induces caprine luteal cells apoptosis via mitochondrial-mediated caspase-dependent pathway. Journal of Biochemical and Molecular Toxicology. 2014. 28(10): 456-464.
60. Jun Zhang#, Dan Xu#, Jia Nie, Jingsong Cao, Yonggong Zhai, Dewen Tong*, Yuguang Shi*. Monoacylglycerol acyltransferase-2 is a tetrameric enzyme that selectively heterodimerizes with diacylglycerol acyltransferase-1. Journal of Biological Chemistry. 2014. 289(15): 10909-10918.
61. Li Ding#, Yong Huang#, Meiling Dai, Xiaomin Zhao, Qian Du, Feng Dong, Lili Wang, Ruichao Huo, Wenlong Zhang, Xingang Xu, Dewen Tong*. Transmissible gastroenteritis virus infection induces cell cycle arrest at S and G2/M phases via p53-dependent pathway. Virus Research. 2013. 178(2): 241-251.
62. Li Ding#, Xiaomin Zhao#, Yong Huang, Qian Du, Feng Dong, Hongling Zhang, Xiangjun Song, Wenlong Zhang, Dewen Tong*. Regulation of ROS in transmissible gastroenteritis virus-activated apoptotic signaling. Biochemical and Biophysical Research Communications. 2013. 442(1-2): 33-37.
63. Feng Dong#, Yong Huang#, Wei Li, Xiaomin Zhao, Wenlong Zhang, Qian Du, Hongling Zhang, Xiangjun Song, Dewen Tong*. The isolation and characterization of a telomerase immortalized goat trophoblast cell line. Placenta. 2013. 34(12): 1243-1250.
64. Yong Huang#, Li Ding#, Zhaocai Li, Meiling Dai, Xiaomin Zhao, Wei Li, Qian Du, Xingang Xu, Dewen Tong*. Transmissible gastroenteritis virus infection induces cell apoptosis via activation of p53 signaling. Journal of General Virology. 2013. 94: 1807-1817.
65. Yong Huang#, Wei Li#, Xiaomin Zhao, Li Ding, Gaoshui Yu, Feng Dong, Qian Du, Xingang Xu, Dewen Tong*. Swainsonine differentially affects steroidogenesis and viability in caprine luteal cells in vitro. Theriogenology. 2013. 80(1): 41-49.
66. Yong Huang, Meng Shao, Xingang Xu, Xiujuan Zhang, Qian Du, Xiaomin Zhao, Wenlong Zhang, Yahui Lyu, Dewen Tong*. Evidence for different patterns of natural inter-genotype recombination between two PCV2 parental strains in the field. Virus Research. 2013. 175(1): 78-86.
67. Xingang Xu#, Honglei Zhang#, Qi Zhang, Jie Dong, Yabing Liang, Yong Huang, Hungjen Liu*, Dewen Tong*. Porcine epidemic diarrhea virus E protein causes endoplasmic reticulum stress and up-regulates interleukin-8 expression. Virology Journal. 2013. 10: 26-33.
68. Xingang Xu#, Honglei Zhang#, Qi Zhang, Yong Huang, Jie Dong, Yabing Liang, Hungjen Liu*, Dewen Tong*. Porcine epidemic diarrhea virus N protein prolongs S-phase cell cycle, induces endoplasmic reticulum stress, and up-regulates interleukin-8 expression. Veterinary Microbiology. 2013. 164(3-4): 212-221.
69. Wenlong Zhang#, Gaoshui Yu#, Yong Huang, Dan Xu, Jingjing Ren, Liang Jiang, Changlong Wu, Dewen Tong*. Expression of ghrelin and GHSR-1a in mammary glands of dairy goat during the lactation and the effects of gherlin on regulation of mammary function in vitro. Molecular and Cellular Endocrinology. 2013. 370(1-2): 20-31.
70. Li Ding#, Xingang Xu#, Yong Huang, Zhaocai Li, Kuan Zhang, Guangda Chen, Gaoshui Yu, Zhisheng Wang, Wei Li, Dewen Tong*. Transmissible gastroenteritis virus infection induces apoptosis through FasL- and mitochondria-mediated pathways. Veterinary Microbiology. 2012. 158(1-2): 12-22.
71. Wei Li#, Xingang Xu#, Yong Huang, Zhaocai Li, Gaoshui Yu, Zhisheng Wang, Li Ding, Dewen Tong*. Establishment and evaluation of a stable steroidogeniccaprine luteal cell line. Theriogenology. 2012. 78(2): 263-272.
72. Xingang Xu#, Guangda Chen#, Yong Huang, Li Ding, Zhaocai Li, Chingdong Chang, Chiyoung Wang, Dewen Tong*, Hungjen Liu*. Development of multiplex PCR for simultaneous detection of six swine DNA and RNA viruses. Journal of Virological Methods . 2012. 183(1): 69-74.
73. Xingang Xu#, Zhisheng Wang#, Qi Zhang, Zhaocai Li, Li Ding, Wei Li, Hungyi Wu, Chingdong Chang, Longhuw Lee, Dewen Tong*, Hungjen Liu*. Baculovirus as a PRRSV and PCV2 bivalent vaccine vector: baculovirusvirions displaying simultaneously GP5 glycoprotein of PRRSV and capsid protein of PCV2. Journal of Virological Methods . 2012. 179(2): 359-366.
74. Xingang Xu, Hongni Zhao, Qi Zhang, Li Ding, Zhaocai Li, Wei Li, Hungyi Wu, Kuopin Chuang, Dewen Tong*, Hungjen Liu*. Oral vaccination with attenuated salmonella entericaserovar typhimurium expressing Cap protein of PCV2 and its immunogenicity in mouse and swine models. Veterinary Microbiology . 2012. 157(3-4): 294-303.
75. Xingang Xu#, Zhisheng Wang#, Qi Zhang, Zhaocai Li, Hongni Zhao, Wei Li, Dewen Tong*, Hungjen Liu*. Baculovirus surface display of E envelope glycoprotein of Japanese encephalitis virus and its immunogenicity of the displayed proteins in mouse and swine models. Vaccine . 2011. 29(4): 636-643.
四、科研项目
近年来主持的科研项目：
1. 国家自然科学基金
2. 中央重大农业技术推广基金
3. 国际科学基金
4. 霍英东教育基金
5. 陕西省科技统筹创新工程计划
6. 陕西省特色产业链项目
五、联系方式
电子邮箱：dwtong@nwsuaf.edu.cn